About Dr. Luke

Dr. Luke's PortraitFor nearly forty years Dr. Luke has published extensively in the areas of maternal nutrition, multiple births, and employment during pregnancy. She is the author, coauthor, or editor of 12 books, and 70 original research papers and over 130 scientific abstracts. Dr. Luke’s research has been funded from both private foundations and federal sources. Her book, When You’re Expecting Twins, Triplets, or Quads (HarperCollins, 3rd edition, 2011) won Outstanding Book of the Year from the American Society of Journalists and Authors in 2000, and has sold more than 100,000 copies. She is the recipient of the 2005 Agnes Higgins Award from the March of Dimes for distinguished lifetime achievement in maternal-fetal nutrition.

Dr. Luke created the University Consortium on Multiple Births, a group of researchers from universities around the country who collaborate on studies to improve outcomes in multiple pregnancies. She developed and maintains a growing database of more than 3,500 twin, triplet, and quadruplet pregnancies, which began with a decade of twin births in Baltimore, Maryland for her doctoral thesis. Her work from 1988-2005 focused on developing prenatal care standards for multiple pregnancies. Her studies have been cited in the American College of Obstetricians & Gynecologists’ Technical Bulletin on Multiple Pregnancy, the New York Times, the Washington Post, and Williams’ Obstetrics.

Since 2006, Dr. Luke has been collaborating with the Society for Assisted Reproductive Technology (SART) in the development of a series of projects to evaluate the health of families after assisted reproductive technology (ART). Current NIH-funded projects include evaluations of the risk of cancer among women treated with ART, and children born from ART. These projects also will compare birth outcomes for the same woman in ART and non-ART pregnancies.

Education
Columbia University, BS, Nursing, 1972
New York, New York

New York University, AM, Foods and Nutrition, 1974
New York, New York
Thesis: Diet Therapy of Renal Disease in the Pre-Dialysis Era: The Biochemical Basis of the Giovanni-Giovannetti Diet

Columbia University, MPH, Population Studies, 1978
New York, New York
Thesis: The Biochemical Effect of Gestational Diabetes on Pregnancy Outcome

Johns Hopkins University, ScD, Maternal & Child Health, 1991
Baltimore, Maryland
Thesis: The Association Between Maternal Weight Gain and the Birthweight of Twins

Current Position
Professor,
College of Human Medicine,
Department of Obstetrics, Gynecology, and Reproductive Biology,
Michigan State University
East Lansing, Michigan

Original Research
1. Luke B and Petrie RH. Intrauterine growth: Correlation of infant birthweight and maternal postpartum weight. Am J Clin Nutr 1980; 33(11):2311-7.

2. Luke B, Hawkins MM, Petrie RH. Influence of smoking, weight gain, and pregravid weight for height on intrauterine growth. Am J Clin Nutr 1981; 34(7):1410-7.

3. Luke B, Dickinson C, Petrie RH. Intrauterine growth: Correlations of maternal nutritional status and rate of gestational weight gain. European J Obstet Gynecol Reprod Biol 1981; 12(2):113-21.

4. Luke B, Jonaitis MA, Petrie RH. A consideration of height as a function of prepregnancy nutritional background and its potential influence on birthweight. J Am Dietet Assoc 1984; 84(2):176-81.

5. Luke B, Witter FR, Abbey H, Feng T, Namnoun AB, Paige DM, Johnson TRB. Gestational age-specific birthweights of twins versus singletons. Acta Genet Med Gemellol 1991; 40(1):69-76.

6. Witter FR, Luke B. The effect of maternal height on birthweight and birthlength. Early Human Development 1991; 25(3):181-6.

7. Luke B, Keith L, Keith D, Johnson TRB. Pregravid weight, gestational weight gain, and current weight of women delivered of twins. J Perinat Med 1991; 19(7):333-40.

8. Luke B, Keith LG, Witter FR. A theoretical model for reducing neonatal morbidity and mortality and associated costs among twins. J Maternal-Fetal Med 1992; 1(1):14-9.

9. Luke B, Keith LG. The contribution of singletons, twins, and triplets to low birthweight, infant mortality, and handicap in the United States. J Reprod Med 1992; 37(8):661-6.

10. Luke B, Minogue J, Abbey H, Keith L, Witter FR, Feng TI, Johnson TRB. The association between maternal weight gain and the birthweight of twins. J Maternal-Fetal Med 1992; 1(5):267-76.

11. Luke B, Keith LG, Damewood MD. Maternal characteristics of women delivered of twins: Natural versus induced. Int J Fertil 1993; 38(1):12-5.

12. Luke B, Minogue J, Witter FR. The role of fetal growth restriction and gestational age on length of hospital stay in twin infants. Obstet Gynecol 1993; 81(6):949-53.

13. Luke B, Minogue J, Witter FR, Keith LG, Johnson TRB. The ideal twin pregnancy: Patterns of weight gain, discordancy, and length of gestation. Am J Obstet Gynecol 1993; 169(3):588-97.

14. Farahati M, Borzorgi N, Luke B. The influence of maternal age, birth-to-conception intervals, and prior perinatal factors on perinatal outcomes. J Reprod Med 1993; 38(10):751-6.

15. Luke B, Keith L, Lopez-Zeno J, Witter FR, Saguil E. A case-control study of the association between maternal gestational weight gain and newborn birthweight and birthlength in twin pregnancies complicated by preeclampsia. Acta Geneticae Medicae Gemellologiae 1993; 42(1):7-15.

16. Luke B. The changing pattern of multiple births in the United States: Maternal and infant characteristics, 1973 and 1990. Obstet Gynecol 1994; 84(1):101-6.

17. Luke B, Minogue J. The contribution of gestational age and birthweight to perinatal viability in singletons versus twins. J Maternal-Fetal Med 1994; 3(6):263-74.

18. Luke B, Mamelle N, Keith L, Munoz F, Minogue J, Papiernik E, Johnson TRB. The association between occupational factors and preterm birth: A United States nurses’ survey. Am J Obstet Gynecol 1995; 173 (3 Pt. 1):849-62.

19. Luke B, Bryan E, Sweetland C, Keith L. Prenatal weight gain and the birthweight of triplets. Acta Geneticae Medicae Gemellologiae 1995; 44(2):93-101.

20. Luke B, Leurgans S, Keith L, Keith D. The childhood growth of twin children. Acta Geneticae Medicae Gemellologiae 1995; 44(3-4):169-78.

21. Luke B, Leurgans S. Maternal weight gains in ideal twin outcomes. J Am Dietet Assoc 1996; 96(2):178-81.

22. Luke B, Bigger HR, Leurgans S, Sietsema D. The cost of prematurity: A case-control study of twins versus singletons. Am J Public Health 1996; 86(6):809-14. PMCID: PMC1380399

23. Luke B, Hediger ML, Scholl TO. The point of diminishing returns: When does gestational weight gain cease benefiting birthweight and begin adding to maternal obesity? J Maternal-Fetal Med 1996; 5(4):168-73.

24. Luke B. Reducing fetal deaths in multiple gestations: Optimal birthweights and gestational ages for infants of twin and triplet births. Acta Geneticae Medicae Gemellologiae 1996; 45(3):333-348.

25. Luke B, Gillespie B, Min S-J, Avni M, Witter FR, O’Sullivan MJ. Critical periods of maternal weight gain: Effect on twin birthweight. Am J Obstet Gynecol 1997; 177(5):1055-62.

26. Luke B, Keith LG, Keith D. Maternal nutrition in twin gestations: Weight gain, cravings and aversions, and sources of nutrition advice. Acta Geneticae Medicae Gemellologiae 1997; 46(3):157-66.

27. Luke B, Min S-J, Gillespie B, Avni M, Witter FR, Newman RB, Mauldin JG, Salman AF, O’Sullivan MJ. The importance of early weight gain on the intrauterine growth and birthweight of twins. Am J Obstet Gynecol 1998; 179(5):1155-61.

28. Luke B, Avni M, Min L, Misiunas R. Work and pregnancy: The role of fatigue and the “second shift” on antenatal morbidity. Am J Obstet Gynecol 1999; 181(5):1172-9.

29. Mozurkewich EL, Luke B, Avni M, Wolfe FM. Working conditions and adverse pregnancy outcomes: A meta-analysis. Obstet Gynecol 2000; 95 (4):623-635.

30. Min S-J, Luke B, Gillespie B, Newman RB, Mauldin JG, Witter, FR, Salman FA, O’Sullivan MJ. Birthweight references for twins. Am J Obstet Gynecol 2000; 182 (5):1250-7.

31. Johnson TRB, Zettelmaier MA, Warner PA, Hayashi RH, Avni M, Luke B. A competency based approach to comprehensive pregnancy care. Women’s Health Issues 2000; 10 (5):240-247.

32. Luke B, Nugent C, van de Ven C, Martin D, O'Sullivan MJ, Eardley S, Witter FR, Mauldin JG, Newman RB. The association between maternal factors and perinatal outcomes in triplet pregnancies. Am J Obstet Gyn 2002; 187:752-7. PMID: 12237659

33. Luke B, Hediger ML, Nugent C, Newman RB, Mauldin JG, Witter FR, O’Sullivan MJ. Body mass index-specific weight gains associated with optimal birth weights in twin pregnancies. J Reproductive Med 2003; 48:217-224. PMID: 12746982

34. Gonzalez-Quintero VH, Luke B, O’Sullivan MJ, Misiunas R, Anderson E, Nugent C, Witter FR, Mauldin JG, Newman RB, D’Alton M, Grainger D, Saade G, Hankins GDV, Macones G. Antenatal factors associated with significant birthweight discordancy in twins. Am J Obstet Gynecol 2003; 189: 813-7. PMID: 14526320

35. Luke B, Brown MB, Misiunas R, Anderson E, Nugent C, van de Ven C, Burpee B, Gogliotti S. Specialized prenatal care and maternal and infant outcomes in twin pregnancy. Am J Obstet Gynecol 2003; 189:934-8. PMID: 14586329

36. Luke B, Brown MB, Gonzalez-Quintero VH, Nugent C, Witter FR, Newman RB. Risk factors for adverse outcomes in spontaneous vs assisted-conception twin pregnancies. Fertility and Sterility 2004; 81:315-9. PMID: 14967366

37. Min S-J, Luke B, Min L, Misiunas R, Nugent C, van de Ven C, Martin D, Gonzalez-Quintero VH, Eardley S, Witter FR, Mauldin JG, Newman RB. Birthweight references for triplets. Am J Obstet Gynecol 2004; 191:809-818.

38. Luke B, Brown MB, Hediger ML, Nugent C, Misiunas RB, Anderson E. Fetal phenotypes and neonatal and early childhood outcomes in twins. Am J Obstet Gynecol 2004; 191:1270-6. PMID: 15507952

39. Luke B, Hediger ML, Min S-J, Brown MB, Misiunas RB, Gonzalez-Quintero VH, Nugent C, Witter FR, Newman RB, Hankins GDV, Grainger DA, Macones GA. Gender mix in twins and fetal growth, length of gestation, and adult cancer risk. Paediatric and Perinatal Epidemiology 2005; 19 (Suppl 1): 41-47. PMID: 15670121

40. Luke B, Brown MB, Alexandre PK, Kinoshi T, O’Sullivan MJ, Martin D, Misiunas RB, Nugent C, van de Ven C, Newman RB, Mauldin JG, Witter FR. The cost of twin pregnancy: Maternal and neonatal factors. Am J Obstet Gynecol 2005; 192:909-15. PMID: 15746690

41. Luke B, Brown MB, Misiunas RB, Mauldin JG, Newman RB, Nugent C, Gonzalez-Quintero VH, Witter FR, Hankins GDV, D’Alton M, Macones G, Grainger D. Elevated maternal glucose concentrations and placental infection in twin pregnancies. J Reproductive Med 2005; 50:241-5. PMID: 15916206

42. Hediger ML, Luke B, van de Ven C, Nugent C. Mid-upper arm circumference (MUAC) changes in late pregnancy predict fetal growth in twins. Twin Research and Human Genetics 2005; 8:267-270. PMID: 15989755

43. Luke B, Brown MB, Misiunas RB, Gonzalez-Quintero VH, Nugent C, van de Ven C, Witter FR, Newman RB, D’Alton M, Hankins GDV, Grainger DA, Macones GA. The Hispanic paradox in twin pregnancies. Twin Research and Human Genetics 2005; 8:532-7. PMID: 16212843

44. Hediger ML, Luke B, Gonzalez-Quintero VH, Witter FR, Mauldin J, Newman RB. Fetal growth rates and very preterm birth of twins. Am J Obstet Gynecol 2005; 193:1498-507. PMID: 16202746

45. Gonzalez-Quintero VH, Tolaymat L, Luke B, Gonzalez-Garcia A, Duthely L, O’Sullivan MJ, Martin D. Outcome of pregnancies among Hispanics: Revisiting the epidemiologic paradox. Journal of Reproductive Medicine 2006; 51:10-14. PMID: 16482770

46. Luke B, Brown MB, Hediger ML, Misiunas RB, Anderson E. Perinatal and early childhood outcomes of twins versus triplets. Twin Research and Human Genetics 2006; 9:81-88. PMID: 16611472

47. Cotter AM, Gonzalez Garcia A, Duthely ML, Luke B, O’Sullivan MJ. Is antiretroviral therapy during pregnancy associated with an increased risk of preterm delivery, low birth weight, or stillbirth? Journal of Infectious Diseases 2006; 193:1195-1201. PMID: 16586354

48. Luke B and Brown MB. The changing risk of infant mortality by gestation, plurality, and race: 1989-91 versus 1999-01. Pediatrics 2006; December; 118:2488-2497. PMID: 17142535

49. Luke B and Brown MB. Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age. Human Reproduction 2007; May; 22(5):1264-72. Epub 2007 Feb 8. PMID: 17289684

50. Luke B and Brown MB. The effect of plurality and gestation on the prevention or postponement of infant mortality: 1989-1991 versus 1999-2001. Twin Research and Human Genetics 2007; June, 10:514-520. PMID: 17564510

51. Luke B and Brown MB. Contemporary risks of maternal morbidity and adverse outcomes with increasing maternal age and plurality. Fertility & Sterility 2007; August; 88:283-93. Epub ahead of print Jan 24. PMID: 17258214

52. Luke B and Brown MB. Maternal risk factors for potential maltreatment deaths among healthy singleton and twin infants. Twin Research and Human Genetics 2007; October; 10:778-785. PMID: 17903121

53. Luke B and Brown MB. Maternal morbidity and infant mortality in twin versus triplet and quadruplet pregnancies. Am J Obstet Gynecol 2008; 198:401.e1-401.e10. PMID: 18177828

54. Messiah SE, Arheart KL, Luke B, Lipschultz SE, Miller TL. Relationship between body mass index and metabolic syndrome risk factors among US 8 to 14 year olds, 1999-2002. J Peds 2008; 153:215-21.PMID: 18534237

55. Gonzalez Guarda RM, Luke B. Contemporary Homicide Risks among Women of Reproductive Age. Women's Health Issues 2009; 19:119-125.

56. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on singleton assisted-conception pregnancy outcomes. Fertility and Sterility 2009; 91:2578-85. PMID: 18565521

57. Luke B, Brown MB, Grainger DA, Stern JE, Klein N, Cedars M. The effect of early fetal losses on twin assisted-conception pregnancy outcomes. Fertility and Sterility 2009; 91:2586-92. PMID: 18804206

58. Luke B, Brown MB, Grainger DA, Baker VL, Ginsburg E, Stern JE. The sex-ratio of singleton offspring in assisted-conception pregnancies. Fertility and Sterility (in press). PMID: 18950756

59. Fujimoto VY, Luke B, Brown MB, Jain T, Armstrong A, Grainger DA, Hornstein M. Racial and Ethnic Disparities in Assisted Reproductive Technology (ART) Outcomes in the United States. Fertility and Sterility 2010; 93:382-90.

60. Stern JE, Brown MB, Luke B, Wantman E, Lederman A, Missmer SA, Hornstein MD. Calculating cumulative live-birth rates from linked cycles of Assisted Reproductive Technology (ART): Data from the Massachusetts SART CORS. Fertility and Sterility 2010; 94:1334-40. PMID: 19596309

61. Luke B, Brown MB, Morbeck DE, Hudson SB, Coddington CC, Stern JE. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on Assisted Reproductive Technology (ART) treatment and outcome. Fertility and Sterility 2010; 94:1399-404. PMID: 19591989

62. Baker VL, Luke B, Brown MB, Alvero R, Frattarelli JL, Usadi R, Grainger DA, Armstrong AY. Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: An analysis of the SART CORS. Fertility and Sterility 2010; 94:1410-6.PMID: 19740463

63. Luke B, Brown MB, Stern JE, Grainger DA, Klein N, Cedars M. Effect of embryo transfer number on singleton and twin implantation pregnancy outcomes after assisted reproductive technology (ART). Journal of Reproductive Medicine 2010; 55:387-394.

64. Manassaram DM, Backer LC, Messing R, Fleming LE,Luke B, Monteilh CP. Nitrates in drinking water and methemoglobin levels in pregnancy: A longitudinal study. Environmental Health 2010; doi:10.1186/1476-069X-9-60. 

65. Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Female obesity adversely affects assisted reproductive technology (ART) pregnancy and live birth rates. Human Reproduction 2011; 26:245-252.

66. Stern JE, Brown MB, Luke B, Wantman E, Lederman A, Hornstein MD. Cycle 1 as predictor of ART treatment outcome over multiple cycles: Analysis of linked cycles from the SART CORS Online Database. Fertility and Sterility 2011; 95:600-605..

67. Luke B, Brown MB, Stern JE, Missmer SA, Fujimoto VY, Leach R. Racial and ethnic disparities in assisted reproductive technology (ART) pregnancy and live birth rates within body mass index (BMI) categories. Fertility and Sterility 2011; 95:1661-6.

 68. Nangia AK, Luke B, Megid WA, Smith J, Mak W, Stern JE. National study of factors influencing assisted reproductive technology (ART) outcomes with male factor infertility. Fertility and Sterility 2011; 96:609-614.

 69. Luke B, Brown MB, Missmer SA, Bukulmez O, Leach R. The Effect of Increasing Obesity on the Response to and Outcome of Assisted Reproductive Technology (ART): A National Study Fertility and Sterility 2011; 96:820-825.

 70. Luke B, Brown MB, Wantman E, Lederman A, Gibbons W, Schattman GL, Lobo RA, Leach RE, Stern JE. Cumulative birth rates from linked assisted reproductive technology cycles. New England Journal of Medicine 2012; 366:2483-91.


Books
1. Luke B. Case Studies in Therapeutic Nutrition. Boston: Little, Brown, 1977. 143 pages. ISBN 0-316-53609-1.

2. Luke B. Maternal Nutrition. Boston, Little, Brown, 1979. 224 pages. ISBN 0-316-5310-5 (also translated into Spanish)

3. Luke B. Principles of Nutrition and Diet Therapy. Boston, Little, Brown, 1984. 816 pages. ISBN 0-316-5311-3. (also translated into Spanish)

4. Luke B. Instructor's Manual for Principles of Nutrition. Boston, Little, Brown, 1984. 130 pages. ISBN 0-316-53612-1.

5. Luke B, Keith LG. Principles and Practice of Maternal Nutrition. London: Parthenon, 1992. 161 pages. ISBN 1-85070-324-8.

6. Luke B, Johnson TRB, Petrie RH: Clinical Maternal-Fetal Nutrition. Boston, Little, Brown, 1993. 335 pages. ISBN 0-316-53614-8.

7. Luke B: Every Pregnant Woman's Guide to Preventing Premature Birth. New York: Times Books/Random House, 1995. 240 pages. ISBN 0-8129-2472-X. (also translated into Spanish)

8. Luke B. Good Bones: the Complete Guide to Building & Maintaining the Healthiest Bones. Palo Alto, Calif.: Bull Publishing, 1998. 173 pages. ISBN 0-923521-44-5.

9. Luke B, Eberlein T. When You're Expecting Twins, Triplets or Quads: A Complete Resource. New York: HarperCollins, 1999. 301 pages. ISBN 0-06-095723-9.

10. Newman RB, Luke B. Multifetal Pregnancy: Care of the Pregnant Patient. Philadelphia: Lippincott-Williams & Wilkins, 2000. 277 pages. ISBN 0-7817-2217-9. (also translated into Spanish)

11. Luke B, Eberlein T. Program Your Baby's Health: The Pregnancy Diet for Your Child's Lifelong Well-being. New York: Ballantine Books (Random House), 2001. 420 pages. ISBN 0-345-44199-0.

12. Luke B, Eberlein T. When You're Expecting Twins, Triplets or Quads: A Complete Resource. New York: HarperCollins, 2004, second edition. 420 pages. ISBN 0-06-095723-9.


13. Luke B, Eberlein T. When You're Expecting Twins, Triplets, or Quads: A Complete Resource. New York:HarperCollins, 2011, 3rd edition. 512 pages. ISBN 0061803073.